med bio 2

Marijuana: No Medical Value?

Subjects receiving 160 mg. cannabidiol reported having slept significantly more than those receiving placebo; seven out of eight epileptics receiving cannabidiol had improvement of their disease state."Hypnotic and Antiepileptic Effects of Cannabidiol" Carlini, E.A., and Cunha, J.A., Journal of Clinical Pharmacology 1981: 21: 417S-427S.

. The antipsychotic activity of CBD is studied on animals used in research with potential antipsychotic properties. CBD seems to compare favorably with haloperidol as an antipsychotic. "Effects of CBD in animal models predictive of anti-psychotic activity," Zuardi, A.W., Rodrigues, J.A., Cunha, J.M., Psychopharmacology 1991: 104: pp. 260-264.

CBD blocks some of the effects of THC in mice but potentiates some other effects. "Pharmacological Interaction between Cannabidiol and Tetrahydrocannabinol" Karniol, I.G., Carlini, E.A., Psychopharmacologia 1973: 33: 53-70.

. CBD was effective in blocking most of the effects of THC, increased pulse rate, disturbed time tasks, and psychological reactions. CBD also decreased the anxiety components of THC. "Cannabidiol Interferes with the effects of Tetrahydrocannabinol in Man" Karniol, I.G., Shirakawa, I., Kasinski, N., Pfeferman, A., Carlini, E.A., European Journal of Pharmacology 1974: 28: 172-177

. Treatment with THC reduced the intensity of abstinence from morphine in rats. These data suggest that THC may be of value in facilitating narcotic detoxification."Morphine-Dependent Rats: Blockade of Precipitated Abstinence by Tetrahydrocannabinol" Hine, B., Friedman, E., Torrelio, M., Gershon, S., Science Feb 1975: Vol. 187: 443-445

Indicates that THC modifies effects of opiates. "Modulation of Rat Brain Opiod Receptors by Cannabinoids" Vaysse, P., Gardner, E.L., and Zukin, R.S., The Journal of Pharmacology and Experimental Therapeutics 1987: Vol. 241, No. 2: 534-539.

THC inhibition of serotonin release during migraine attacks may give a clue to the way cannabinoids relieve this condition "Cannabinoids Block Release of Serotonin from Platelets Induced by Plasma from Migraine Patients" Volfe, Z., Dvilansky, A., Nathan, I., Int. J. Clin. Pharm. Res. 1985: V(4) 243-246.

Short-term chronic marijuana use does not have a substantial adverse effect on B or T cells of young healthy adults."Intact humoral and cell-mediated immunity in chronic marijuana smoking" Rachelefsky, Gary S., Opelz, G., et al, Journal of Allergy and Clinical Immunology 1976: Vol 58, No. 4: 483-490.

Lewis lung adenocarcinoma growth was retarded in mice treated with THC and CBN and survival time was increased by up to 36% compared to controls. "Antineoplastic Activity of Cannabinoids" Munson, A.E., Harris, L.S., et al, Journal of the National Cancer Institute, Vol. 55, No. 3, Sept. 1975, 597-602.

>>>>I especially like this last one. Now you know the real reason Marijuana has been classified as a Schedule I Controlled Substance!!! It may be TOO anti-carcinogenic.